Table 3.10: Summary of human safety data of hydrogen peroxide in mouth-rinses
| Peroxide formulation |
n |
Dosage regimen |
Safety findings |
Reference |
| 1.5% Hydrogen peroxide rinse |
30 subjects |
rinsed 4 times a day for 7 days |
No treatment-related effects reported |
Winer et al., 1991 |
| 1.5% Hydrogen peroxide rinse |
93 test 85 control |
rinsed 3 times a day for 7 days |
No treatment-related effects reported |
Gomes et al., 1984 |
| 1.5% Hydrogen |
30 |
rinsed once a day |
No generalized |
Boyd, 1989 |
| peroxide rinse |
children |
for 18 months |
mucosal irritation was noted |
|
| 6-12.5% Hydrogen peroxide rinse |
88 dental students |
2-3 times a day for 1-2.5 months |
Some gingival changes. 6,.4% showed “redder” gums and 3.4 paler gums. 6.6% developed hyperkeratinised filiform papillae of the tongue |
Müller et al, 1938 |
| Hydrogen |
(not |
21 days |
No adverse effects |
Purdue |
| peroxide/sodium |
stated) |
|
reported |
University, |
| bicarbonate system |
|
|
|
1990 |
| 3% Hydrogen peroxide rinse |
(not stated |
rinsed 3 to 5 times a day |
Mucosal irritation in 2 individuals with prior tissue injury |
Rees and Orth, 1986 |
| 3% Hydrogen |
(not |
|
No adverse effects |
Herrin et al., |
| peroxide with |
stated) |
|
reported |
1987 |
| sodium bicarbonate |
|
|
|
|
| 1.5% Hydrogen peroxide rinse |
(not stated) |
18 months |
No adverse effects reported |
Fischman et al., 1992 |
| 1.5% Hydrogen peroxide rinse |
(not stated) |
Twice daily for 24 months |
Improved gingival heath |
Gangler and Staab, 1985 |
| 0.75 or 1.5% Hydrogen peroxide rinse |
(not stated) |
4 times daily for 5 weeks |
Discoloration of mucosal surfaces |
Tombes and Gallucci, 1993 |
| 1.5% Hydrogen peroxide rinse |
(not stated) |
2 months |
No adverse effects reported |
Shibly et al., 1997 |
Source:
SCCP
Opinion on Hydrogen peroxide, in its free form or when released, in oral hygiene products (2007), p.44
Related publication:
Other Figures & Tables on this publication:
Table 3.1: Summary of in vitro genotoxicity of hydrogen peroxide (IARC, 1999)
Table 3.2. Summary of in vivo genotoxicity of hydrogen peroxide (ECB, 2003)
Table 3.3. Incidence of gastro-duodenal lesions in C57BL/6J mice after receiving hydrogen peroxide in the drinking water (Ito et al., 1981)
Table 3.4. Incidence of duodenal tumours in 4 strains of female mice treated with 0.4% H2O2 in drinking water (Ito et al., 1984)
Table 3.5. Effect on gastro-duodenal carcinogenesis induced by MNNG (Takahashi et al, 1986)
Table 3.6: Hydrogen peroxide exposure in mouse dermal and hamster check pouch tumour promotion assays following initiation by with DMBA
Table 3.7: Summary of clinical studies using hydrogen peroxide toothpastes
Table 3.8: Adverse events in clinical trials with toothpastes containing up to 3% hydrogen peroxide (unpublished company data)
Table 3.9: Unfavourable reports received to marketed toothpaste with 0.75% hydrogen peroxide in the period 1995-1997(unpublished company data)
Table 3.10: Summary of human safety data of hydrogen peroxide in mouth-rinses
Table 3.11: Unfavourable reports received to marketed mouth-rinse with 0.75% hydrogen peroxide in the period 1995-1997 (unpublished company data)
Table 3.12. Available hydrogen peroxide in the saliva during the first 30 and 60 minutes
Table 3.13. Concentration of hydrogen peroxide in the strip, at the teeth, at the gingival, and in the saliva during the first 60 minutes.
