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Table 13-4: Fragrance substances categorised as possible contact allergens.
Opinion on fragrance allergens in cosmetic products

INCI name (or, if none exists, perfuming name according to CosIng) CAS number Human evidence: see text EC 3 value (min; %) SAR
 Individual chemicals
CYCLOHEXYL ACETATE 622-45-7 limited none 0
ETHYLENE DODECANEDIOATE 54982-83-1 limited none 0
HYDROXYCITRONELLOL 107-74-4 limited none 0
METHOXYTRIMETHYLHEPTANO L 41890-92-0 limited none 0
METHYL p-ANISATE 121-98-2 limited none 0
METHYL DIHYDROJASMONATE 24851-98-7 limited none 0
PHENETHYL ALCOHOL 60-12-8 limited none 0
PHENYLPROPANOL 122-97-4 limited none 0
AMYLCYCLOPENTANONE 4819-67-4 negative none +
BENZYL ACETATE 140-11-4 negative none +
6-ETHYLIDENEOCTAHYDRO-5,8-METHANO-2H-BENZO-1-PYRAN 93939-86-7 negative none +
3α,4,5,6,7,7α-HEXAHYDRO-4,7-METHANO-1H-INDEN-5(OR 6)-YL ACETATE 54830-99-8 negative none +
alpha-IONONE 127-41-3 negative none +
beta-IONONE  79-77-6 negative none +
METHYL IONONE (mixture of isomers) 1335-46-2 negative none +
TERPINEOL ACETATE (Isomer mixture) 8007-35-0 negative none +
alpha-TERPINYL ACETATE 80-26-2 negative none +
CITRONELLYL NITRILE 51566-62-2 none none ++
alpha-CYCLOHEXYLIDENE BENZENEACETONITRILE 10461-98-0 none none +
DECANAL 112-31-2 none none ++
DIHYDROMYRCENOL 18479-58-8 none none +
3,7-DIMETHYL-1,6-NONADIEN-3-OL 10339-55-6 none none ++
2-ETHYL-4-(2,2,3-TRIMETHYL-3-CYCLOPENTEN-1-YL)-2-BUTEN-1-OL 28219-61-6 none none +
GERANYL ACETATE 105-87-3 none none ++
HEXAHYDRO-METHANOINDENYL PROPIONATE 68912-13-0 none none +
IONONE isomeric mixture 8013-90-9 none none +
ISOBERGAMATE 68683-20-5 none none +
METHYL DECENOL 81782-77-6 none none +
TRICYCLODECENYL PROPIONATE 17511-60-3 none none +
OXACYCLOHEXADECENONE 34902-57-3 none none ++
VERDYL ACETATE 2500-83-6/ 5413-60-5 none none +
trans-beta-Damascone 23726-91-2 none none +
gamma-Damascone 35087-49-1 none none +
Citronellal  106-23-0 none none ++
Phenethyl salicylate 87-22-9 none none ++
Natural extracts
ACORUS CALAMUS ROOT OIL 84775-39-3 Limited none
CEDRUS DEODARA WOOD OIL 91771-47-0 Limited none
CITRUS AURANTIUM AMARA LEAF OIL 72968-50-4 Limited none
CITRUS TANGERINA … 223748-44-5 Limited none
CYMBOPOGON NARDUS / WINTERIANUS HERB OIL 89998-15-2; 91771-61-8 Limited none
ILLICIUM VERUM FRUIT OIL 84650-59-9 Limited none
LAVANDULA SPICA 97722-12-8 Limited none
LITSEA CUBEBA 90063-59-5 Limited none   
PELARGONIUM ROSEUM 90082-55-6 Limited none   
SALVIA spp. Diverse Limited none   
TAGETES PATULA 91722-29-1 Limited none   
THYMUS spp. 84929-51-1 Limited none   
VETIVERIA ZIZANOIDES 8016-96-4; 84238-29-9 Limited none   

Source: SCCS,  Opinion on Fragrance allergens in cosmetic products, pages 111-113

Related publication:
Allergies homePerfume Allergies
Other Figures & Tables on this publication:

Table 4-1: Ingredients of Fragrance Mix I (FM I; 8% allergens in petrolatum).

Table 4-2: Ingredients of Fragrance Mix II (FM II; 14% allergens in petrolatum).

Table 4-3: Results with screening agents for contact allergy to fragrance ingredients reported since 1999 in patients patch tested for suspected allergic contact dermatitis in Europe: Fragrance Mix “I” (see Table 4-1). If not given in the publication, the confidence interval (CI) was calculated from the absolute numbers by the SCCS (§).

Table 4-4: Results with screening agents for contact allergy to fragrance ingredients reported since 1999 in patients patch tested for suspected allergic contact dermatitis in non-European countries: Fragrance Mix “I” (see Table 4-1). If not given in the publication, the confidence interval (CI) was calculated from the absolute numbers by the SCCS (§).

Table 4-5: Results with screening agents for contact allergy to fragrance ingredients reported since 1999 in patients patch tested for suspected allergic contact dermatitis: Fragrance Mix “II” (see Table 4-2). The FM II was only conceived in 2005, so results are still sparse). If not given in the publication, the confidence interval (CI) was calculated from the absolute numbers by the SCCS (§).

Table 4-6: Results with fragrance contact allergy screening agents reported since 1999 in patients patch tested for suspected allergic contact dermatitis: HICC (5% pet. if not stated otherwise). If not given in the publication, the confidence interval (CI) was calculated from the absolute numbers by the SCCS (§).

Table 4-7: Results with fragrance contact allergy screening agents reported since 1999 in patients patch tested for suspected allergic contact dermatitis: Myroxylon pereirae resin (Balsam of Peru) (25% pet.). If not given in the publication, the confidence interval (CI) was calculated from the absolute numbers by the SCCS (§).

Table 4-8: Results with fragrance contact allergy screening agents reported since 1999 in patients patch tested for suspected allergic contact dermatitis: Oil of turpentine (10% pet.) patients patch tested for suspected allergic contact dermatitis. If not given in the publication, the confidence interval (CI) was calculated from the absolute numbers by the SCCS (§).

Table 4-9: Results from patch testing with Fragrance Mix I in different population based groups.

Table 4-10: Results from patch testing with other fragrance allergens in different population based groups. If not given in the publication, the confidence interval (CI) was calculated from the absolute numbers by the SCCS (§).

Table 4-11: Extract from ((65) Table 3) regarding the proportion of patients with “present clinical relevance” (see text) and “past clinical relevance” (criteria not given).

Table 4-12: Extract from ((106) Table 2) on the frequency of positive reactions to fragrance allergens in patients with vs. without positive patch test reaction to their own deodorant.

Table 4-13: Extract from ((106) Table 2) on the frequency of positive reactions to fragrance allergens in patients with vs. without positive patch test reaction to their own aftershave, eau de toilette or perfume.

Table 5-1: Contact allergic reactions to the autoxidised fragrance substances limonene, linalool, caryophyllene, myrcene and linalyl acetate in consecutive dermatitis patients.

Table 5-2: Contact allergic reactions to limonene, linalool, linalyl acetate and caryophyllene in consecutive dermatitis patient. Please observe that several studies have been performed using the test substances without reporting the autoxidation status but it has been intended to be low. For precise information see the original references.

Table 5-3: Concomitant reactions to fragrance markers: Fragrance Mix I and II (FM I, FM II), Myroxylon pereire (MP) and to colophonium (coloph.) in the baseline series in patients with positive or negative patch test reactions to oxidised fragrance substances.

Table 5-4: Mean and median content of isoeugenol and its derivatives in the 29 perfume products.

Table 7-1: Established contact allergens in humans (summary of evaluation as detailed in chapter 6.3). More detailed information forming the basis of this evaluation can be found in Annex I of this opinion.

Table 7-2: Fragrance substances with positive human data, which are, however, not sufficient to categorise as “established contact allergen in humans”. More detailed information forming the basis of this evaluation can be found in Annex I of this opinion.

Table 7-3: Fragrance substances with negative human data, i.e. patch tests of patients with suspected contact allergy to fragrance ingredients which yielded negative results.

Table 7-4: Fragrance substances lacking human data and used in high volumes according to industry information.

Table 7-5: Natural extracts classified as established contact allergens in humans (summary of evaluation as detailed in chapter 6.3). More detailed information forming the basis of this evaluation can be found in Annex I of this opinion, including variants of botanical nomenclature.

Table 7-6: Natural extracts with positive human data, which are, however, not sufficient to categorise as “established contact allergen in humans”. More detailed information forming the basis of this evaluation can be found in Annex I of this opinion.

Table 7-7: Indicative list illustrating natural extracts containing established human allergens or having R43-lable or positive LLNA, lacking published human data.

Table 8-1: Summary of local lymph node assay (LLNA) data on 66 fragrance substances, based on a report submitted by the Research Institute for Fragrance Materials, Inc. (RIFM, 2009 (164)) and in published reviews by Gerberick et al. 2005 (165) and Kern et al. 2010 (166), respectively. EC3 values (% and M) are given. The order of substances is by decreasing sensitisation potency as assessed by LLNA EC3 values (lowest EC3 value indicating highest potency).

Table 8-2: Local lymph node assay (LLNA) data on four fragrance substances and one essential oil before and after air exposure, comparing the sensitisation potency of the pure (not oxidised) substance with the potency of the oxidised.

Figure 8-1: The distribution of fragrance chemicals and a variety of other chemicals

Table 8-3: Summary of EC3 values for fragrance substances in Table 8-1 and for other substances, all taken from the three references (164-166). The EC3 value intervals for potency categorisation (161, 205) were used for comparison of fragrances substances vs other substances.

Table 9-1: Predicted sensitisers.

Table 9-2: Possible sensitisers.

Table 9-3: Predicted non-sensitisers with no obvious structural alerts.

Table 9-4: Not predictable.

Table 10-1: Presence in children's cosmetics of the 26 fragrance substances that are required to be labelled in cosmetics (227).

Table 10-2: Usage trends in deodorants of fragrance chemicals that are required to be labelled in cosmetics.

Table 10-3: Frequency of occurrence in consumer products of the 26 fragrance allergens that are required to be labelled in cosmetics and detergents (229).

Table 10-4: Frequency in 516 consumer products of the 26 fragrance substances that are required to be labelled in cosmetics* (115).

Figure 10-1: Frequency of occurrence in 3,000 consumer products of the 26 fragrance allergens that are required to be labelled in cosmetics and detergents.

Table 10-5: Concentration of Fragrance Mix I ingredients in five prestige perfumes before and after the regulation of the 26 fragrance allergens.

Table 10-6: Concentrations of Fragrance Mix I ingredients, hexyl cinnamal and coumarin in 22 perfumes marketed as natural cosmetics investigated in 1996.

Table 10-7: Atranol and chloroatranol content in eau de toilette/eau de perfume, investigated in 2004 and in 2007.

Table 10-8: Parts of Annex I to (EC) No 1451/2007 (see above): “Active substances identified as existing”, if use is ‘perfuming’ or ‘masking’ according to CosIng.

Table 10-9: Result of a Poisson regression analysis of patients tested with the Fragrance Mix

Table 10-10: Association between selected risk factors and positive patch test to Myroxylon pereirae resin. For full model see (269). Risk quantified with the prevalence ratio (PR) with accompanying 95% confidence interval (CI).

Table 11-1: Current IFRA restrictions based on induction experiments.

Table 11-2: Spearman’s rank correlation between the threshold concentration in the patch test and the repeated open application test for three allergens.

Figure 11-1: The fitted dose-response curve for patch test

Table 11-3: Overview of results of deodorant provocation investigations with different allergens. Frequency in % of test groups, which reacted at different doses of allergen applied in a roll-on deodorant in the axilla, is given in the table.

Table 11-4: Overview of threshold results from clinical studies.

Table 11-5: Concentration limits in different product types based on 0.8 μg/cm2 allergen as a 'generally safe exposure level', if specific dose-response data are unavailable.

Table 11-6: Overview of dose-response studies and thresholds for eight allergens, after (280).

Figure 11-2: The threshold data with 95% confidence intervals from Table 11-6 presented graphically, after (280).

Figure 11-3: The fitted dose-response curves from the studies in Table 11-6, which are the basis for estimation of the ED10 value, after (280).

Table 11-7: Restriction for HICC independent of the QRA according to (293).

Figure 11-4: Time trend of hydroxyisohexyl 3-cyclohexene carboxaldehyde sensitisation prevalence

Figure 11-5: Prevalence of positive patch test reactions to hydroxyisohexyl 3-cyclohexene carboxaldehyde

Table 13-1: Established contact allergens in humans.

Table 13-2: Fragrance substances categorised as established contact allergens in animals.

Table 13-3: Fragrance substances categorised as likely contact allergens by combination of evidence.

Table 13-4: Fragrance substances categorised as possible contact allergens. Opinion on fragrance allergens in cosmetic products

Table 13-5: Established fragrance contact allergens of special concern (single chemicals only).

Table 13-6: Known prehaptens and prohaptens.